The convergence of the Internet of Things (IoT) with Generative AI and emerging Agentic AI marks a new chapter in digital transformation. Industries such as manufacturing, energy, mobility, and healthcare stand to benefit from intelligent agents that not only process sensor data but also act autonomously, simulate scenarios, and optimize decisions in real time. This enables new use cases—from predictive maintenance and energy-aware smart grids to personalized healthcare and safer mobility systems. Yet adoption is not without hurdles: edge-to-cloud integration, data quality, interoperability, and reliability pose technical challenges, while data protection, liability, and compliance with evolving AI and cybersecurity regulations raise legal and ethical questions. This panel will explore where IoT, GenAI, and Agentic AI deliver the greatest impact, which industries lead adoption, and how organizations can overcome the barriers to unlock the next wave of intelligent, connected solutions.